Nice find, the only other thing I could think of was the CADWorx Settings.
SaveLastProfileUsed should always be set to NO

SaveLastProfileUsed
Default value: No
Allowed values: No or Yes
Specifies whether CADWorx saves the last profile used on exit. When a drawing file is double-clicked in Windows Explorer, or if the CAD platform is started using an icon without specifying any profile, the CAD platform always loads the last profile used.
No Prevents CADWorx from saving the last profile used.
Yes Allows CADWorx to save the last profile used.