My opinion is that this will provide numbers, but they'll probably be non-sensical except perhaps for simple systems without non-linearities or sign changes with/without friction.

If axial friction at node 1 prevents lateral load at node 2, whereas frictionlessness would produce a higher lateral load at node 2, it's not necessarily accurate to conclude that the F2(frictionless)-F2(friction) is necessarily due to friction at node 2, but rather friction interplay between nodes 1 and 2.

Expand onto this that guides may have gaps, +y supports may be lifted off from, secondary effects of lines moving in the opposite direction, etc.

You could end up with Fx at node 101 = -1000 units with friction and +1000 units without friction - thus friction must be doing 2000 units of force, right?

Well, no, the support isn't actually throwing 2000 units of force - that's just everything working in tandem.