Yes and no.

Moving one end laterally relative to the other end necessitates the connecting body to not only bend once but twice. So "yes."

However, the ends are still expected to be mostly controlled with guides, etc such that you're effectively dealing with just lateral motion, so as to avoid over compression/expansion on the device. This seems like it would be fairly difficult to reliably ascertain if you have significant rotation of your pipe and equipment. So "no."

Add to this that EJ manufacturers tend to require you to install EJs horizontally so as to specifically avoid many of these problems.

Finally, if you have "significant" rotation, you may need to look at alternative technologies, such as ball joint assemblies.