What difference it makes if the support is from the top or the bottom?
From a pipe stress standpoint, little, if none. Tension versus compression. But that's what CAESAR tells you.
One way gravity assists you in keeping your piping configuration. The other way gravity fights you in keeping your piping configuration.
If for whatever reason you lose your guides, you could either be moderately unsafe, or you can be at risk of catastrophic failure.
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