Please see
http://65.57.255.42/ubbthreads/ubbthreads.php?ubb=showflat&Number=60362

I've attached few sketches there; in my opinion it is a good example to understand that your in-line component is a part of a piping system that may be subject to bending- for example. How much bending- this depends on the piping configuration and can be calculated by software (Caesar, for example), taking into consideration piping configuration (including restraints) as well the loads (weights, temperature, pressure, seismic, wind) applied to piping configuration.
The fact your in-line component may experience also some movements- for example from a status of system with T1 temperature to other status having T2 temperature, it is of little importance for this discussion; it is important to know the sectional loads (axial and shear forces, bending and torsional moments) in every section of the piping system, in every state of the piping system. The nozzles of your in-line component shall be such sections of interest for you.