(This advise is based on our systems which are fairly simple BD lines you need to asses Your situation to suit!)

My advise is to run at worst case.
If you cannot get a satisfactory solution,
then keep refining the model.

There will come a point using static analysis where you have
A- a good solution.
B- No solution.

If you cannot get a satifactory solution using
static analysis, then assess how large your overstress's are.
If you feel you can have (Code compliance)
by further refining the model using dynamic analysis, then do so.
But this is a time-costly exersise.
otherwise a piping redesign is in order.

I would be very suprised unless you have excesive conditions that a static analysis will not suffice.

Regards