im curious if any of y'all know of a way to have Isogen bubble isos with mark numbers from a master BOM not independent of each other sheet to sheet? what would this workflow look like to get this to work?

I am not sure I am understanding the question ? Could you clarify or share an example ?

Iso #1 BOM 1-20
Iso #2 BOM 21-36
ISO #3 BOM 37-42
etc...

all numbering aligning with an exported master BOM may be what he meant?

I know that you can tell the BOM "prompt" to drop at desired number

We do this in Structure:
skid 100s
platform 200s
pipe supports 300
ladder 400
etc...

I am not sure of any way to automate this. You can assign BOM part marks in ICEDIT, but that would be a purely manual process.

Repeatability return will do this automatically, but I very much doubt you will be able to assign marks before the first run.

There is a great third party tool to do this. Check out BUBBLEWorx

I've done this in-house as well.