Dear Sir,
In general, most pressure vessel codes mandate that non-isolated openings be checked for closeness. ASME is no exception. Please check ASME VIII-1 paragraphs UG-40 and UG-42 for information regarding limits of reinforcing and multiple openings. In some cases it may be necessary to modify the limits of reinforcement to obtain a viable geometry.
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Scott MayeuxCADWorx & Analysis Solutions
Intergraph Process, Power, & Marine