If all of the elements in the model are connected, then you only need to set the coordinates of the first node.
In your above example, node 100 won't be connected to 300 unless either:
a) you change node 300 to 100 (or 100 to 300)
b) or you associate 300 to 100 with a CNODE.
Simply specifying the coordinates of node 300 (which would be possible since the model is disconnected) to match those of 100 would make things look connected graphically - but they really wouldn't be.
As stated above, coordinates are required if you're applying environmental loads. Other than that, specifying the actual coordinate of the first node is optional. (You may want to do this as a aid in geometry verification, but it won't affect the analysis.)
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Regards,
Richard Ay - Consultant