Dear,
As in any pipe system, you have to support the pipe and guide it. As stress analyst, you decide where to suppot (+Y), where to support and guide (+y & GUIDE) or where only guide.
Your supports must properly work for your load cases, and if you have big loads in your vertical pipe run and you consider you have to reduce it, maybe spring is required.
Study the pipe system and give proper suppurting based on your stress criterion.
Regards.