Do not thake my words for granted but from what I know (and I don't know much, just to put the things straight), in case of tube rupture, fluid will flash, so there is not a such major concern of slug. You should study howerver if RD is appropiate for this as it will not close anymore, so you will continue to deinventory your system.
You will have some flow induced forces. Up to you how you will calculate this.
Regards,
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Dan