Amachree,
I know this could be too late but in case I need jut to share my opinion. though I did not see your layout, I can realize that your pipeline failed in a guide simply becuase it did not have sufficient flexibility to expand horizontally. A guide restarint the pipe to move horizonatally. On some cases, try giving a gap to your guide starting from small figure like 1/16" to a higher one (even 3" or more if it works) and if the stresses pass that's the right guide for you. In your case, the system pass when you chaneg it to a +Y simply because +Y restaint the pipe only from going down - meaning it is simply a vertical support and it is free to go up. Technically, since you came from a guide, I would assume you use a +Y and an X or Z either with gap or without a gap. You could still have a guide without a vertical support but I would only assume you have a vertical support. So when you change it only +Y (maybe you have only removed the X or Z as your guide leaving the +Y), your line pass the code check because you have let the pipe expand horizontally. This is not a general rule. The concept is, study the piping flexibility and how to retraint them so to contain stresses and overloading on supports. Just keep on studying and make some trials on Caesar if you can.
Ed-Lamigo
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Ed-Lamigo