The more you are out of the range of WRC-107/297, the less accurate the results will be.
So, you should see the curve in the WRC-107/297 bulletins to check it.
You should also try the other methods, nozzle reinforcement, App. 1-10/1-7 for large nozzles, code minimum wall thickness, WRC-297, WRC-368 and most important your experience.
In my opinion, if the curves are not exceeded by much and if the stresses are well below the allowables then the design probably is ok. So, you have to utilize your prior design experience.
Otherwise, use a finite element analysis program to check that nozzle.
Another aspect of the issue is how accurate are your piping Loads :-) I am going there.
_________________________
Best Regards,
Mandeep Singh
CADWorx & Analysis Solutions
Hexagon PPM