I'm working on a stress analysis for a client that requires restraint loads to be given/evaluated with friction included and nozzle loads to be given/evaluated without friction.

Is there an easy way to do this in CAESAR? The only way I know of is to run it once with friction. Then I would have to go back to the input and manually turn off friction at each restraint before I run it again.

There is a collumn called friction multiplier in the load case tab (Loadcase editor). Assigning a zero here should remove friction from the respective loadcases I believe.

Yes, this is correct. Just duplicate the required load cases, and for one set us a multiplier of 1.0 and for the other a multiplier of 0.0. I suggest you use the "load case name" option here to keep things straight, or you'll mix things up at the output level.